A Simple Post, RE: Good Times

I was downloading and editing pictures this morning, and I came across all these wonderful ones from a dinner party our friends had for us before my surgery. Heidy, Greg, Marty, Letti, Mike, Thoren, Jim, Julie, and Geoff and their kids organized this wonderful gathering at a fancy restaurant in Queen Elizabeth Park called Seasons. Chloe and Mylo were psyched to get dressed up in fancy clothes and see their little friends. It was in a private room, so the kids could run around and go wild.

Here are the two little rascals before leaving for dinner.


Totally a daddy's girl, eh?


Mylo doing his usual calisthenics before eating--his secret to maintaining his buff physique. What a show-off! Wonder where he gets that trait from...


Our friends Marty and Letti's little guy, Marcus


All the kids playing something or other before eating.


Even Heidy and Greg's son, Gryphen, enjoys getting in on the food action!


Mr. Mylo


Ms. Chloe. Um, yeah, even princesses get runny noses...


...and princesses like to lick their runny noses...


...and shove food in their maws.



I think that last picture sums it up. We had a great time with great friends. And now I'm going to plug my other blog where I also put up more new pictures of the kiddins. Enjoy!

Researchers Find that a Small Molecule Can Activate an Important Cancer Suppressor Gene

Auntie Em!

Some really bad storms ripped through our part of Kansas City at around 2 a.m. today. One of my friends lives in a neighborhood that was heavily damaged; some of the houses around hers were completely destroyed. The storms also ripped the roof off of a preschool that some other friends attend. Compared to that, there was hardly any damage in our neighborhood. We were very, very lucky. The worst ordeal I had to face was the fact that WCK's sandbox lid had blown under our neighbors' deck. I had to walk across the lawn to get it at 7 a.m. in my pajamas (a Wizard of Oz t-shirt I've had since eighth grade, pink flannel pants with gingerbread men all over them, bright pink flip flops, hair standing on end), and wound up encountering a neighbor who has a Real Job and thus was dressed like a Real Person at 7 a.m. She didn't make fun of my gingerbread man pants, though.

Still coughing up crud

I feel like I am getting another cold/ bug coughing up crud, tired often, but I can't sleep. Most of the stuff that I cough up happens in the A.M. I think it is just crap that builds up in my lungs overnight.

Fat-Derived Stem Cell Enhanced Breast Reconstruction for Lumpectomy Repair

Article by Pam Stephan

Cytori Celution Improves Soft Tissue Transplantation
A lumpectomy is less drastic than having a mastectomy, but it leaves you with a scar and a dimple where a smooth, full curve used to be. The breast can also end up much smaller causing significant breast asymmetry in some women. This asymmetry is often exacerbated by the contraction (shrinkage) caused by the radiation therapy that usually follows lumpectomy. An investigational breast reconstruction technique is being studied that uses your own fat and stem cells to repair the shape of your breast. This technique is called Cell-Enhanced Reconstruction, and was presented at the 2007 San Antonio Breast Cancer Symposium.

A Technique for Partial Breast Reconstruction
Women who have had breast-conserving surgery (lumpectomy, partial mastectomy) currently do not have any options for breast reconstruction. Mastectomy patients can choose from implants and tissue flap procedures for recreating a lost breast, but lumpectomy patients have been left behind - until now.

Japanese Investigational Study
Dr. Keizo Sugimachi, of Kyushu Central Hospital in Fukuoka, Japan, has used this new fat graft procedure on 21 patients, 79% of which said they were pleased with the results. His colleague, Dr. Kitamura, who led the Japanese study, said, "The investigational procedure offers hope to partial-mastectomy patients who have limited options," said Dr. Kitamura. "Unfortunately the concept of 'breast conserving therapy' can often times be misleading, as even minimally invasive resections can result in defects that leave patients dissatisfied with the cosmetic outcome."

Stem Cell Enhanced Breast Reconstruction
Cell-enhanced reconstruction uses your own fat tissue (adipose) that is a rich source of stem and regenerative cells. These stem cells are not the controversial embryonic stem cells. Soft tissue transplants have been done for many years, but this new procedure uses a special process to ensure that the transplanted cells will live and adapt to the transplantation site. The process was developed by Cytori, and uses a machine called CelutionTM System EU.

Stem and Fat Cell Liposuction and Injection
Cytori Celution System is used to remove fat and stem cells. These cells are processed to create a mixture of concentrated stem cells combined with fat cells. This concentrated mixture is injected into your lumpectomy area in 3 places, to fill out the missing tissue. Your breast won't immediately look like it has been repaired; it will need about a month for the transplanted cells to settle into position and fill out the lumpectomy cavity.

The Reconstruction Technique:
1: Standard liposuction removes fat, regenerative, and stem cells from abdomen.
2: Cells go into the Cytori Celution processing system
3: Celution system separates regenerative and stem cells from fat cells. The regenerative and stem cells are then washed and concentrated.
4: The concentrated stem cell mixture is combined with the fat cells.
5: The final mixture is injected into the lumpectomy area, where it fills in and replaces tissue volume.

One Surgical Procedure
Fat cells (adipose tissue) can be extracted from your abdomen, thighs, hips, or lower back. Only one surgical procedure is required for this breast reconstruction technique. In the Japanese study, patients were followed for up to 18 months after the procedure, with no loss of tissue volume and no recurrence of breast cancer.

Planned Clinical Studies
Women who participate in a clinical trial of cell-enhanced reconstruction must be recovered from their breast conservation surgery and any follow-up treatments, and must be recurrence-free for at least two years. There will be two clinical trials in Europe during 2008, which will involve about 90 patients. If approved, clinical studies will begin in the United States after 2008.

Sources:
1) Kitamura K, et al "Stem cell augmented reconstruction: a new hope for reconstruction after breast conservation therapy" Breast Cancer Res Treat 2007; 106 (Supp1): Abstract 4071.
2) Medpage Today. Medical News from SABCS: San Antonio Breast Cancer Symposium Meeting. Fat-Derived Stem Cells Used for Breast Reconstruction. Published: December 17, 2007.
3) Cytori Therapeutics. Cytori Therapeutics Receives FDA 510(k) Clearance for the Cytori Fat Transfer System. Published: December 12, 2007.

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Susan's Eggsellent Adventure

Five months after my auto stem cell transplant, can I still use "chemo brain" as an excuse.

Check out the latest post on Open Mouth, Insert Fork and decide for yourself.

Carcinomas of ovary and lung with clear cell features: can immunohistochemistry help in differential diagnosis?