From the Editor

I'll be taking some time away from blogging for the remainder of 2010. My tentative plan is to return with a different approach. For example, it may rely much less on blog posts, and more on short news items that can be found via a search of the real-time feed aggregator FriendFeed (FF) for the hashtag #cancerSC. An advantage of FF is that it permits news items and comments to be added by anyone who joins FriendFeed, and thus fosters a more community-oriented approach.

CSC news roundup 2010-04-11

• Cancer Stem Cells: Back to Darwin? (review) [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/csTyxT


• Cancer stem/progenitor cells are highly enriched in CD133+CD44+ population in hepatocellular carcinoma [FriendFeed entry][PubMed citation] http://bit.ly/bwUz7C


• The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation [FriendFeed entry][News release][PubMed citation] http://bit.ly/cCjVZL


• Hedgehog Signaling and Cancer Stem Cells in Hematopoietic Cell Malignancies (USPTO Application) [FriendFeed entry] http://bit.ly/bSbbTF


• (WO2010037134) Multi-stage stem cell carcinogenesis [FriendFeed entry][WIPO entry] http://bit.ly/cnksOu


• (WO2010037041) Frizzled-binding agents and uses thereof (to target CSC ) [FriendFeed entry] http://bit.ly/aaSJNI


• Epithelial-Mesenchymal Transition (EMT) in Tumor-Initiating Cells and Its Clinical Implications in Breast Cancer (review) [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/cEcBrJ


• Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/cvoGt1


• Emerging strategies for the identification and targeting of cancer stem cells (review) [FriendFeed entry][PubMed citation] http://bit.ly/bGOGfd


• Stem cells in human breast cancer (OA review) [FriendFeed entry][ResearchGATE entry][PubMed citation] http://bit.ly/aF9E8U


• Side-population cells in luminal-type breast cancer have tumour-initiating cell properties, and are regulated by HER2 expression and signalling [FriendFeed entry][PubMed citation] http://bit.ly/92VkLU


• Hypoxia inducible factors in cancer stem cells (minireview) [FriendFeed entry][PubMed citation] http://bit.ly/bGBdxN


• Classic view of cancer challenged by new theory (about the CSC model) [FriendFeed entry] http://bit.ly/decqFe


• New hope in the horizon: cancer stems cells (OA review) [FriendFeed entry][PubGet entry][Full text PDF] http://bit.ly/9HLmV0

CSC news roundup 2010-03-27

• The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/cfLPyK


• Expansion of CD133+ colon cancer cultures retaining stem cell properties to enable cancer stem cell target discovery [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9NLTZ8


• Loss of heterozygosity of the tumor suppressor gene Tg737 in the side population cells of hepatocellular carcinomas is associated with poor prognosis [FriendFeed entry][PubMed citation] http://bit.ly/dCQGYL


• Cancer Stem Cells: The Final Frontier for Glioma Virotherapy [FriendFeed entry][CiteULike entry][PubMed citation] http://bit.ly/c8GeYb


• MUC4 down-regulation reverses chemoresistance of pancreatic cancer stem/progenitor cells and their progenies [FriendFeed entry][ResearchGATE entry][Connotea bookmark][PubMed citation] http://bit.ly/cvcfX7


• Expression of Pluripotent Stem Cell Reprogramming Factors by Prostate Tumor Initiating Cells [FriendFeed entry][PubMed citation] http://bit.ly/9jtqLK


• Molecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cells [FriendFeed entry] [ResearchGATE entry][PubMed citation] http://bit.ly/9xWial


• Cancer stemness and metastasis: Therapeutic consequences and perspectives [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9s0W14


• Gene-expression profiles, tumor microenvironment, and cancer stem cells in breast cancer: Latest advances towards an integrated approach [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/dgqE0n


• Molecular biology of breast cancer stem cells: Potential clinical applications [FriendFeed entry][PubMed citation] http://bit.ly/as3m3j


• In Situ Identification of Putative Cancer Stem Cells by Multiplexing ALDH1, CD44, and Cytokeratin Identifies Breast Cancer Patients with Poor Prognosis [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9rXuWC


• c-Jun Induces Mammary Epithelial Cellular Invasion and Breast Cancer Stem Cell Expansion [FriendFeed entry][PubMed citation] http://bit.ly/aInNB2


• The Utility and Limitations of Neurosphere Assay, CD133 Immunophenotyping and Side Population Assay in Glioma Stem Cell Research [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9O4PtL


• Methods of assaying sensitivity of cancer stem cells to therapeutic modalities (USPTO Application) [FriendFeed entry][FreshPatents entry] http://bit.ly/dcWhtJ


• Cancer Stem Cells [Book and Media Reviews] JAMA 2010(Mar 17);303(11):1098 [FriendFeed entry][Book contents] http://bit.ly/9PY8xP


• Challenges in the development of future treatments for breast cancer stem cells (OA review) [FriendFeed entry] http://bit.ly/9DGutB

CSC news roundup 2010-03-16

• microRNA-34a is tumor suppressive in brain tumors and glioma stem cells [FriendFeed entry][CSC News post][PubMed citation] http://bit.ly/a5onzu


• Enrichment for breast cancer cells with stem/progenitor properties by differential adhesion [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/ceskEY


• miR-29a initiates AML by converting myeloid progenitors into self-renewing leukemia SC? [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9sM8Mw


• Oncolytic viral purging of leukemic hematopoietic stem and progenitor cells with Myxoma virus [FriendFeed entry][PubMed citation] http://bit.ly/c0SRla


• @sciclips MicroRNA as a target for the inhibition of glioblastoma stem cells [FriendFeed entry] http://bit.ly/cvXSwu


• @sciclips The most complete systems biology study of cancer stem cell (CSC) differentiation to date [FriendFeed entry][PubMed citation] http://bit.ly/cBe4D3


• Presentations on Geron’s Telomerase Inhibitor At AACR Special Conference (Business Wire) [FriendFeed entry] http://bit.ly/cFmyWp


• CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9ZmKqT


• Targeting leukemia stem cells (by inducing them to divide) [FriendFeed entry][CiteULike entry][PubMed citation] http://bit.ly/aVquQk


• RT @cancer_news: [Reflection and Reaction] HER2 as a cancer stem-cell target [FriendFeed entry][PubMed citation] http://is.gd/9udQM


• Evidence for self-renewing lung CSCs & their implications [FriendFeed entry][Connotea bookmark][ResearchGATE entry][PubMed citation] http://bit.ly/cje8cc


• Cancer as a reprogramming-like disease: Implications in tumor development and treatment [Connotea bookmark][PubMed citation] http://bit.ly/csHdxT


• RT: @cancer_news Identification of the cell lineage at the origin of basal cell carcinoma [FriendFeed entry][PubMed citation] http://is.gd/9sT10


• Alpha-fetoprotein producing cells act as cancer progenitor cells in human cholangiocarcinoma [FriendFeed entry][CiteULike entry][PubMed citation] http://bit.ly/bp6dnS


• Efficacious Immune Therapy in CML Recognizes Antigens That Are Expressed on CML Progenitor Cells [FriendFeed entry][PubMed citation] http://bit.ly/briNv0


• Notch-Blocking Drugs Kill Brain Cancer Stem Cells http://bit.ly/bQqs4f about [PubMed citation] http://bit.ly/cJZ5e3


• Universal cancer vaccine containing cancer stem cells [FriendFeed entry] http://bit.ly/bDn5R8


• Dock-and-lock (DNL) anti-cancer vaccine for multiple myeloma cancer stem cells [FriendFeed entry] http://bit.ly/csGN8N

CSC news roundup 2010-02-28

• Tumor initiation via loss of cell contact inhibition versus Ras mutation: Do all roads lead to EMT? [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/bIYZjW


• CD133+ cells are more resistant to anticancer drugs than CD133- cells in neuroblastoma cell lines [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/bCJKkI


• Breast cancer chemoresistance: Emerging importance of CSC [FriendFeed entry][ResearchGATE entry][PubMed citation] http://bit.ly/cmgfj4


• Neoplastic stem cells: Current concepts and clinical perspectives [Connotea bookmark][PubMed citation] http://bit.ly/9cRlm2


• Nature Methods: Renaissance of classical pathology? Autofluorescence helps identify CSC in glioma [FriendFeed entry][Connotea bookmark][PubMed citation] http://ow.ly/1ag7d


• New tool illuminates connections between stem cells and cancer [FriendFeed entry] http://bit.ly/9GLmQC


• ALDH Associated With Worse Overall Survival in Patients With Pancreatic Adenocarcinoma [FriendFeed entry][News release][PubMed citation] http://bit.ly/982S5B


• ABCG2: a potential marker of stem cells and novel target in stem cell and cancer therapy [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/clJSiU


• Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9A2kHC


• Radiation Resistance of CSC - The 4R's of Radiobiology Revisited [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/ddLt3N


• Evaluation of the frequency of putative prostate CSC in primary and metastatic prostate cancer [FriendFeed entry][PubMed citation] http://bit.ly/dba5IN


• Immunobiological Characterization of CSC Isolated from Glioblastoma Patients [FriendFeed entry][PubMed citation] http://bit.ly/9t2ReY


• Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer [PubMed citation] http://bit.ly/d17EGn


• Side population and cancer stem cells: therapeutic implications [PubMed citation] http://bit.ly/ceNr2Y


• PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice [FriendFeed entry][CiteULike entry][PubMed citation] http://bit.ly/c9VQTa


• Pancreatic cancer stem cells: new understanding of tumorigenesis, clinical implications [PubMed citation] http://bit.ly/agqb1E


• Targeting Cancer Stem Cells: Therapeutic Strategies and Pipeline Developments (Content, Jan 2010) [FriendFeed entry][BioPortfolio] http://bit.ly/cZzr3R


• Short (<2 min) video about researching pancreatic CSC at UCLA [FriendFeed entry] http://ow.ly/16NCQ


• Lecture: Max Wicha – The CSC hypothesis: biological and clinical implications (57 min) [FriendFeed entry] http://bit.ly/dhKdGD

CSC news roundup 2010-02-13

• ABCG5-positivity in tumor buds is an indicator of poor prognosis in node-negative colorectal cancer patients [FriendFeed entry][Connotea bookmark][PubMed citation][Full text PDF] http://bit.ly/94fqTs


• Good cells gone bad: the cellular origins of cancer [Connotea bookmark][PubMed citation] http://bit.ly/crHb0Y


• Targeted Cancer Stem Cell Therapies Start with Proper Identification of the Target - Letter [Connotea bookmark][PubMed citation] and Response [Connotea bookmark][PubMed citation]


• Transcriptional Profiles of CD133+ and CD133- Glioblastoma-Derived Cancer Stem Cell Lines Suggest Different Cells of Origin [Connotea bookmark][PubMed citation] http://bit.ly/b255Ec


• ALDH1A1(+) cell population enriched in tumor-initiating cells, associated with progression of bladder cancer [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/bDj1yx


• Association of stem cell marker CD133 expression with dissemination of glioblastomas [Sciencia entry][Connotea bookmark][PubMed citation] http://bit.ly/b3azCE


• NO signaling in perivascular niche promotes stem-like characteristics in glioma cells [FriendFeed entry][PubMed citation] http://bit.ly/c8Enie


• TGF-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/bivZQu


• Selective targeting of radiation-resistant tumor-initiating cells [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/chw0Fi


• CSC from colorectal cancer-derived cell lines [FriendFeed entry][News release][PubMed citation] http://bit.ly/bDxxnM


• Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia SC [FriendFeed entry][News release] http://bit.ly/9g8yUJ


• Heterogeneity for Stem Cell-Related Markers According to Tumor Subtype and Histologic Stage in Breast Cancer [Connotea bookmark][PubMed citation] http://bit.ly/aVE3SF


• Hypothesis: co-existing active-quiescent pools of CSC sub-populations? [FriendFeed entry][PubMed citation] http://bit.ly/acMHpi


• Disarming Specialized SC Might Combat Deadly Ovarian Cancer [FriendFeed entry][PubMed citation] http://bit.ly/cTpNTM


• A seminal finding for prostate cancer? [Article summary][Topsy entry][PubMed citation] http://bit.ly/7jCq2n


• Dissecting Cancer Stem Cell Theories [FriendFeed entry] http://bit.ly/9oilZA

CSC news roundup 2010-01-31

• Hypoxia inducible factors in CSC [FriendFeed entry] [Connotea bookmark]


• Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer [FriendFeed entry] http://is.gd/73pVk


• Evidence for self-renewing lung cancer stem cells and their implications [FriendFeed entry] [Connotea bookmark]


• The elaboration of a critical framework for understanding cancer: the CSC hypothesis [FriendFeed entry][Connotea bookmark]


• IMUC’s ICT-107 vaccine product candidate targets CSC [FriendFeed entry] http://bit.ly/5BnV5q


• Putative CSC markers show strong prognostic significance in colorectal cancer [FriendFeed entry][Connotea bookmark] http://bit.ly/7uUuOZ


• Cell of Origin Identified for Common Type of Breast Cancer [FriendFeed entry] http://bit.ly/4B0GOl http://bit.ly/5n9Icz


• Cancer Biomarker Chase Accelerates [FriendFeed entry] http://bit.ly/57iVWN


• CSC suppress immune response against brain tumor [FriendFeed entry] http://bit.ly/6HgW1g


• About a new report: Targeting CSC: Therapeutic Strategies and Pipeline Developments [FriendFeed entry] http://bit.ly/8mfqET


• More evidence that tumours, like healthy organs, grow from SC. The Economist, 14 Jan 2010 [FriendFeed entry] http://bit.ly/4AeekG


• AC133 Epitope, but not the CD133 Protein, Is Lost upon CSC differentiation [FriendFeed entry] http://bit.ly/6r2aGh


• Nanosystems capture and destroy circulating tumor cells (CTC) [FriendFeed entry] http://bit.ly/7ebzXI


• Evidence that CSC escape and down-regulate host antitumor immunity [FriendFeed entry] http://bit.ly/5vWN8n http://bit.ly/5wgRBV


• Stem cells linked to an aggressive cancer of childhood [FriendFeed entry] http://bit.ly/73ldYl http://bit.ly/6YaniV


• Role for the SCF-c-kit signaling axis in self-renewal and proliferation of human lung CSC [FriendFeed entry] http://bit.ly/6PxEyW


• High-throughput screening of tumor-initiating cells in zebrafish [FriendFeed entry] http://bit.ly/6G06No


• The Telomerase Antagonist, Imetelstat, Efficiently Targets Glioblastoma Tumor-Initiating Cells [FriendFeed entry] http://icio.us/t0td2z


• OncoMed, Fluidigm to Analyze Tumor Cell Populations [FriendFeed entry] http://bit.ly/7GnYvm


• Therapy which fails to target CSC can actually promote malignant features in the recurring tumor! [FriendFeed entry] http://bit.ly/6h7jOp


• CXCR1 blockade selectively targets human breast CSC in vitro and in xenografts [FriendFeed entry] http://bit.ly/69ynfK

CSC news roundup 2010-01-16

• Medium and Device for Proliferation of Stem Cells and Treatment of Cancer-Related Stem Cell with Resveratrol, United States Patent Application 20100010099. Via FreePatentsOnline.com. Publication Date: January 14, 2010. Assignees: Taipei Veterans General Hospital. [Patentdocs entry].


• Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content by Salvatore Pece and 9 co-authors, including Pier Paolo Di Fiore, Cell 2010(Jan 8); 140(1): 62-73. [Connotea bookmark][FriendFeed entry].


• Regulating Cancer Stem Cells the miR Way by Marcus E Peter, Cell Stem Cell 2010(Jan 8); 6(1): 4-6. [Commentary on Nat Cell Biol 2009(Dec);11(12):1487-95].


• BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells by Mirle Schemionek and 16 co-authors, including Steffen Koschmieder, Blood 2010(Jan 6) [Epub ahead of print][PubMed Citation][Connotea bookmark].


• Blocking inflammation receptor kills breast cancer stem cells, study finds, News Release, University of Michigan Health System, January 4, 2010. [About: J Clin Invest doi:10.1172/JCI39397][FriendFeed entry][Another FriendFeed entry].


• Geron Announces Publication of Data on Its Telomerase Inhibitor in Glioblastoma, Business Wire, January 4, 2010. [About: Clin Cancer Res 2010(Jan 1);16(1):154-63][FriendFeed entry].


• Primary brain tumors, neural stem cell, and brain tumor cancer cells: Where is the link? By Isabelle Germano, Victoria Swiss and Patrizia Casaccia, Neuropharmacology 2010(Jan 1) [Epub ahead of print][PubMed Citation][Connotea bookmark].


• Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity by Andrea Sottoriva, Joost JC Verhoeff and 6 co-authors, Cancer Res 2010(Jan 1); 70(1): 46-56. [PubMed Citation][FriendFeed entry][ResearchGATE entry].


• The therapeutic promise of the cancer stem cell concept by Natasha Y Frank, Tobias Schatton and Markus H Frank. Review in J Clin Invest 2010(Jan); 120(1): 41-50. [PubMed Citation][ResearchGATE entry].


• Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironment, Breast Cancer Res Treat 2009(Nov 13) [Epub ahead of print][PubMed Citation][MDLinx Oncology Summary][FriendFeed entry].

CSC news roundup 2010-01-03

• Glioma stem cell research for the development of immunotherapy, Neurosurg Clin N Am 2010(Jan); 21(1): 159-66 [PubMed Citation][Connotea bookmark].


• Cancer stem cell and niche, Front Biosci (Schol Ed) 2010(Jan 1); 2: 184-93 [PubMed Citation][FriendFeed entry][Connotea bookmark].


• Cancer stem cell niche as a therapeutic target by Alexey Bersenev, Hematopoiesis, December 27, 2009 [FriendFeed entry].


• Leukemia Stem Cells, Semin Cancer Biol 2009(Dec 22) [Epub ahead of print][PubMed Citation][Connotea bookmark].


• Aldehyde Dehydrogenase 1–Positive Cancer Stem Cells Mediate Metastasis and Poor Clinical Outcome in Inflammatory Breast Cancer, Clin Cancer Res 2009(Dec 22) [Epub ahead of print][PubMed Citation][FriendFeed entry][Connotea bookmark].


• Multiple lineages of human breast cancer stem/progenitor cells identified by profiling with stem cell markers, PLoS ONE 2009(Dec 21); 4(12): e8377 [PubMed Citation][Full text via PMC][ResearchGATE entry][Connotea bookmark].


• Are cancer stem cells concentrated in more alkaline hypoxic regions of tumors? Med Hypotheses 2009(Dec 16)[Epub ahead of print][PubMed Citation].


• Targeted therapy in haematological malignancies, J Pathol 2009(Dec 10) [Epub ahead of print][PubMed Citation][ResearchGATE entry][Connotea bookmark].


• Video of Robert Weinberg interviewed about Breast Cancer Stem Cells & the EMT, SABCS 2009 Interview, American Association for Cancer Research, December 10, 2009 [FriendFeed entry].


• Professor Dick Honored For Making Sense of Cancer Stem Cells by Mikkael A Sekeres, ASH News Daily, December 8, 2009 [FriendFeed entry].


• Spices halt growth of breast stem cells, study finds, PhysOrg.com, December 7, 2009 [FriendFeed entry].

CSC news roundup 2009-12-24

• An adult tissue-specific stem cell molecular phenotype is activated in epithelial cancer stem cells and correlated to patient outcome by Thomas Hussenet and 4 co-authors, including Stanislas du Manoir, Cell Cycle 2010(Jan 23); 9(2) [Epub ahead of print][PubMed Citation][Connotea bookmark].


• Differential Destruction of Stem Cells: Implications for Targeted Cancer Stem Cell Therapy by Mary E Sehl and 3 co-authors, including Kenneth L Lange, Cancer Res 2009(Dec 15); 69(24): 9481-9 [PubMed Citation][Connotea bookmark][ResearchGATE entry].


• EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance by Mario-Luca Suvà and 12 co-authors, including Ivan Stamenkovic, Cancer Res 2009(Dec 15); 69(24): 9211-8 [PubMed Citation][Connotea bookmark].


• Hypoxia-Regulated Delta-like 1 Homologue Enhances Cancer Cell Stemness and Tumorigenicity by Yuri Kim and 3 co-authors, including Zhong Yun, Cancer Res 2009(Dec 15); 69(24): 9271-80 [PubMed Citation][Connotea bookmark].


• Cancer Stem Cells and Aneuploid Populations within Developing Tumors Are the Major Determinants of Tumor Dormancy by Anjali P Kusumbe and Sharmila A Bapat, Cancer Res 2009(Dec 15); 69(24): 9245-53 [PubMed Citation][ResearchGATE entry].


• Stem-like cancer cells are inducible by increasing genomic instability in cancer cells by Yi Liang and 9 co-authors, including Yi-Xin Zeng, J Biol Chem 2009(Dec 9) [Epub ahead of print][PubMed Citation][Early version of full text].


• Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells by Michiko Murohashi and 9 co-authors, including Noriko Gotoh, Br J Cancer 2009(Dec 8) [Epub ahead of print][PubMed Citation][ResearchGATE entry].


• Brain Tumor Cells Made More Responsive to Radiation, ScienceDaily, December 3, 2009 [Stem Cells 2009(Nov 17)]][PubMed Citation].


• SOM scientists explore spice as complementary treatment option for colorectal cancer, Prognosis E-news, Wayne State University School of Medicine, November 24, 2009 [Transl Oncol 2009(Dec);2(4):321-8][PubMed Citation].


• Is ALDH1 a good method for definition of breast cancer stem cells? by Veronique Neumeister and David Rimm, Breast Cancer Res Treat 2009(Nov 28) [Epub ahead of print][PubMed Citation][Connotea bookmark].


• Single-Cell STAT5 Signal Transduction Profiling in Normal and Leukemic Stem and Progenitor Cell Populations Reveals Highly Distinct Cytokine Responses by Lina Han and 5 co-authors, including Jan Jacob Schuringa, PLoS ONE 2009(Nov 24); 4(11): e7989 [PubMed Citation][Full text in PMC][Connotea bookmark].


• Recurrent hepatocellular carcinoma cells with stem cell-like properties: possible targets for immunotherapy by Xiaolan Xu‌ and 8 co-authors, including Zhiqian Zhang‌, Cytotherapy 2009(Nov 24) [Epub ahead of print][PubMed Citation][Connotea bookmark].

CSC news roundup 2009-11-26

• Distinct population of highly malignant cells in a head and neck squamous cell carcinoma cell line established by xenograft model, 7thSpace Interactive, November 16, 2009 [J Biomed Sci 2009(Nov 16);16(1):100 (OA)][PubMed Citation][FriendFeed entry].


• Tumor-initiating Cells Detected in Pten Null Prostate Cancer Model, PhysOrg.com, November 12, 2009 [Cancer Res 2009(Nov 15); 69(22):8555-62][PubMed Citation][FriendFeed entry].


• Mouse Models for Cancer Stem Cell Research by Le Cheng and 4 co-authors, including Alexander Y Nikitin, Toxicol Pathol 2009(Nov 17) [Epub ahead of print][PubMed Citation].


• Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironment by Erika Resetkova and 6 co-authors, including Sunil Badve, Breast Cancer Res Treat 2009(Nov 13) [Epub ahead of print][PubMed Citation][Connotea bookmark].


• Recognition and Killing of Brain Tumor Stem-Like Initiating Cells by CD8+ Cytolytic T Cells by Christine E Brown and 10 co-authors, including Michael C Jensen, Cancer Res 2009(Nov 10) [Epub ahead of print][PubMed Citation][Connotea bookmark].


• Notch Pathway Blockade Depletes CD133-Positive Glioblastoma Cells and Inhibits Growth of Tumor Neurospheres and Xenografts by Xing Fan and 14 co-authors, including Charles G Eberhart, Stem Cells 2009(Nov 10) [Epub ahead of print][PubMed Citation][Connotea bookmark].


• Targeting breast stem cells with the cancer preventive compounds curcumin and piperine by Madhuri Kakarala and 8 co-authors, including Max S Wicha, Breast Cancer Res Treat 2009(Nov 7) [Epub ahead of print][PubMed Citation].


• Identification of single chain antibodies to breast cancer stem cells using phage display by Deniz Gur and 5 co-authors, including Max S Wicha and David N Krag, Biotechnology Prog 2009(Nov 6) [Epub ahead of print][PubMed Citation].


• Methodologies in assaying prostate cancer stem cells by Hangwen Li and 7 co-authors, including Dean G Tang, Methods Mol Biol 2009; 568: 85-138 [PubMed Citation].


• Pituitary adenoma stem cells by Patrizia Tunici and John S Yu, Methods Mol Biol 2009; 568: 195-201 [PubMed Citation].


• Targeting breast cancer stem cells by Max S Wicha, The Breast 2009(Oct); 18(Suppl 3): S56-8.

CSC news roundup 2009-11-10

• The cancer stem cell microenvironment and anti-cancer therapy by Veerander P S Ghotra, Jordi C Puigvert and Erik H J Danen. Review in Int J Radiat Biol 2009(Nov); 85(11): 955-62 [PubMed Citation].


• Cancer Stem Cells : A Reality, A Myth, A Fuzzy Concept or A Misnomer? An Analysis by Carine Maenhaut, Jacques E Dumont, Pierre Roger and Wilma C G van Staveren. Review in Carcinogenesis 2009(Oct 25) [Epub ahead of print][PubMed Citation].


• Colorectal cancer stem cells by Paul Salama and Cameron Platell, Review in ANZ J Surg 2009(Oct); 79(10): 697-702 [PubMed Citation][FriendFeed entry].


• Identification and targeting of cancer stem cells by Tobias Schatton, Natasha Y Frank and Markus H Frank. Review in Bioessays 2009(Oct); 31(10): 1038-49 [PubMed Citation].


• Cancer stem cells: Symmetry is key by Mhairi Skinner, Nature Reviews Cancer 2009; 9: 768-9. A commentary about [Cell 2009 Sep 18;138(6):1083-95][FriendFeed entry].


• On cancer stem cells (for the lay public) [All Things Stem Cell 2009(Oct 31)] by Teisha Rowland [FriendFeed entry].


• Immunoselection of breast and ovarian cancer cells with trastuzumab and natural killer cells. [Cancer Res 2009(Oct 15);69(20):8058-66][PubMed Citation][FriendFeed entry].


• CD133 Expression Defines a Tumor Initiating Cell Population in Primary Human Ovarian Cancer by Michael D Curley and 10 co-authors, including Bo R Rueda and Rosemary Foster. Stem Cells 2009(Oct 8) [Epub ahead of print][PubMed Citation].

CSC news roundup: 2009-11-02

• Compositions and Methods for Determining Cancer Stem Cell Self-Renewal Potential, University of California, San Diego Technology Transfer Office, November 2, 2009. [SD2009-192][Tech ID: 19976].


• ImmunoCellular's Promising Brain Cancer Vaccine, Mike Havrilla, Seeking Alpha, October 28, 2009. [Reuters News Release].


• MicroRNA Regulation of Cancer Stem Cells and Therapeutic Implications, Jeffrey T DeSano and Liang Xu, AAPS J 2009(Oct 20). [PubMed Citation].


• Sphere and/or xenograft formation may be useful to survey colitic patients at risk of developing cancer? [Cancer Res 2009 (Oct 15);69(20):8208-15][PubMed Citation][News Release].


• Recent studies regarding stem cell origin of various solid tumors are discussed briefly in this review. [Onkologie 2009 (Oct);32(10):605-9][PubMed Citation].


• Squelching glioblastoma stem cells by targeting REST for proteasomal degradation by Peisu Zhang and 4 co-authors, including Jeremy N Rich and Mark P Mattson, Trends Neurosci 2009(Nov);32(11):559-65 [Epub 2009(Sep 11)][PubMed Citation].


• Methylation dosage effect controls stem cell function in leukemia. [Nat Genet 2009 (Nov);41(11):1207-15][PubMed Citation][News Release].

CSC news roundup: 2009-10-06

• Tumour-initiating cells: challenges and opportunities for anticancer drug discovery by Bin-Bing S Zhou and 5 co-authors, including Peter B Dirks, Nat Rev Drug Discov 2009(Oct); 8(10): 806-23 (Review) [PubMed Citation].


• The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype by John M Heddleston and 4 co-authors, including Jeremy N Rich, Cell Cycle 2009(Oct 3); 8(20) [Epub ahead of print][PubMed Citation].


• Identification of a myeloid committed progenitor as the cancer initiating cell in acute promyelocytic leukemia by Florence C Guibal and 11 co-authors, including Daniel G Tenen, Blood 2009(Oct 1) [Epub ahead of print][PubMed Citation].


• Targeting leukaemia at the roots by Alison Ross, Science Update blog, Cancer Research UK, September 28, 2009.


• "Tax-ing" the cancer stem cell by Gerold Feuer, Blood 2009(Sep 24); 114(13): 2568-9 [PubMed Citation].


• Cancer stem cell research gains traction, tackles new targets by Katherine Harmon, Scientific American, September 23, 2009 [FriendFeed entry].


• A progenitor cell origin of myeloid malignancies by Hiroshi Haeno, Ross L Levine, D Gary Gilliland and Franziska Michor, Proc Natl Acad Sci USA 2009(Sep 29); 106(39): 16616-21 [Epub 2009(Sep 21)][PubMed Citation].


• Vitro's Cancer Stem Cell Therapy Complements New Hedge Hog Drugs, News Release, September 10, 2009 [Vitro Biopharma].


• Cancer stem cells in breast cancer and metastasis by Jessica C Lawson, Gregory L Blatch and Adrienne L Edkins, Breast Cancer Res Treat 2009(Sep 4) [Epub ahead of print] (Review). [PubMed Citation].


• Cancer stem cell genomics: the quest for early markers of malignant progression by Oswaldo K Okamoto, Expert Rev Mol Diagn 2009(Sep); 9(6): 545-54 (Review). [PubMed Citation].