Showing posts with label ovarian cancer. Show all posts
Showing posts with label ovarian cancer. Show all posts

Wednesday, September 22, 2010

Mysterious Blue Lights


[Andrew Nelles photo}

Lately I noticed that some buildings in the Loop had blue lights on top and I couldn't figure out why. It couldn't be for Halloween, and I don't associate Columbus Day (Indigenous Peoples Day in Berkeley) with any color at all except maybe those of the Italian flag. Which aren't blue. After ROW practice on Monday, as we sat on the outside patio of the nearby Gem Bar (No Sam Adams, no Goose Island, we're not the North Side--said nicely) someone mentioned that the blue lights were actually were teal, for Ovarian Cancer Awareness Month, which is September. Then today's Trib had a piece on it. There's a fundraiser Friday night. Some of our rowers have ovarian, uterine and other cancers. Some have what's called "mets," which means their cancer has metastasized. And some still row. And some don't.

Sunday, June 13, 2010

Decitabine may target ovarian CSCs?

Two-Drug Phase I Trial Shows Promise in Treating Late-Stage Ovarian Cancer, ScienceDaily, June 13, 2010. Excerpt:
"Our hypothesis is that decitabine isn't just targeting active ovarian cancer cells, but also cancer stem cells that seem to survive the first treatments," [Kenneth] Nephew said. "By keeping tumor suppression genes from being methylated, carboplatin and other platinum-based treatments for ovarian cancer have a better chance of success in the late stages."
This news release is about the publication entitled: A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer by Fang Fang, Curt Balch and 9 co-authors, including Kenneth P Nephew and Daniela E Matei, Cancer 2010(Jun 8) [Epub ahead of print].

Sunday, August 23, 2009

Ovarian CSCs play a role in tumor neovascularization?

Stem-like Ovarian Cancer Cells can Serve as Tumor Vascular Progenitors by Ayesha B Alvero and 8 co-authors, including Gil Mor, Stem Cells 2009(Aug 5) [Epub ahead of print]. PubMed Abstract:
Neovascularization is required for solid tumor maintenance, progression, and metastasis. The most described contribution of cancer cells in tumor neovascularization is the secretion of factors, which attract various cell types to establish a microenvironment that promote blood vessel formation. The cancer stem cell hypothesis suggests that tumors are composed of cells that may share the differentiation capacity of normal stem cells. Similar to normal stem cells, cancer stem cells (CSCs) have the capacity to acquire different phenotypes. Thus, it is possible that CSCs have a bigger role in the process of tumor neovascularization. In this study, we show the capacity of a specific population of ovarian cancer cells with stem-like properties to give rise to xenograft tumors containing blood vessels, which are lined by human CD34+ cells. In addition, when cultured in high-density Matrigel, these cells mimic the behavior of normal endothelial cells and can form vessel-like structures in 24h. Microscopic analysis showed extensive branching and maturation of vessel-like structures in 7 days. Western blot and flow cytometry analysis showed that this process is accompanied by the acquisition of classical endothelial markers, CD34 and VE-cadherin. More importantly, we show that this process is VEGF-independent, but IKKbeta-dependent. Our findings suggest that anti-angiogenic therapies should take into consideration the inherent capacity of these cells to serve as vascular progenitors.

Wednesday, March 11, 2009

Good news about ovarian cancer?



A study shows that the CA-125 blood test and ultrasounds can help diagnose ovarian cancer in post-menopausal (which is the same as menopausal) women before it has metastasized. Ovarian cancer, you may recall, is what Gilda Radner died of. It's called the whisper disease because the symptoms are so subtle: bloating, pelvic or abdominal pain, feeling full quickly, frequent urination.

The study isn't final and there's a caveat: However, the results so far leave two major issues unsettled: what the ideal method of screening is and whether finding ovarian cancer early will actually help women live longer,Katherine Hobson reports in the US News & World Report.

Women who have an average risk of getting ovarian cancer don't need to be tested, according to the American Cancer Society.

I read Gilda Radner's memoir almost 20 years ago and I remember how painful it was to read her blaming herself for the cancer--having to do with an eating disorder, I think. For all we know, she could have had a gene mutation that led to the cancer. I hate blaming the victim. For example, I read that stress and "low social support" can help ovarian and other cancers along. A study shows this. What is stress? It's the release of norepinephrine and epinephrine. Stress can be measured. The effect of stress hormones on cancer cells can be measured. I do not like this. I've been trying to remain calm for the last two weeks. I say to myself, I am calm. It works some of the time. But I get agitated easily. When I got my last mammogram, in January, I was in a waiting room for women who had had breast cancer. One woman who was my age, thin and Romanian with designer eyeglasses, said that after breast cancer she had changed her whole life--eating better, eliminating stress. Cancer as a wakeup call: You must change your life, as Rilke told us in another setting. In a museum, upon seeing a torso of Apollo. Changing is the most difficult thing a person can do. I eat more vegetables, I think; that's how I explain my lowered cholesterol. I want to be a morning person. I want not to have things bother me. I want to be calm and relaxed without taking my assortment of pills: Effexor, Buspar (generic), Wellbutrin XL. I want my asthma to go away. Yoga has helped people with asthma, my now-retired yoga teacher J used to say but I don't feel that it's changed mine much. I've been at it for maybe eight years. I want to get up with the sun and exercise every day. I want to not do things at the last minute. I want to clean my desk. I want to be organized. I want to live a long time.

The young Rilke, we are told, had writer's block, and was counseled by the much-older Rodin to go to the Paris zoo and look "until you capture the essence of the animal." Rodin's motto: travailler, toujours travailler. Work, always work. Work will save you. (That comes perilously close to Arbeit macht frei.)

We have lost much of the physicality associated with writing. Everyone sits at a computer now, not just the writer. There are no quills, no sand (to help dry the ink), no inkwells, no blotting paper, no typewriting that must be stopped at a certain hour so it won't disturb the neighboring tenants. Technology is changing, always changing, and we keep up with it or not. I want to stop it. I want to burn all the Kindles and iPods and iPhones because I don't understand them. Stop them all, like Faust wanting to burn his books. But we've come too far.

Faust doesn't look so happy:

Friday, January 9, 2009

Autophagy and tumor dormancy in human ovarian cancer cells

The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells by Zhen Lu and 11 co-authors, including Robert C. Bast, Jr., J Clin Invest 2008(Dec 1); 118(12): 3917-29. [PubMed Citation]. The last sentence of the Abstract:
Thus, ARHI can induce autophagic cell death, but can also promote tumor dormancy in the presence of factors that promote survival in the cancer microenvironment.
A Commentary: Autophagy-induced tumor dormancy in ovarian cancer by Ravi K Amaravadi, J Clin Invest 2008(Dec 1); 118(12): 3837-40. PubMed Abstract:
Autophagy--a process of "self-eating" that involves enzymatic digestion and recycling of cellular constituents in response to stress--contributes to both cancer cell death and survival. In this issue of the JCI, Lu et al. report that controlled induction of tumor suppressor gene aplasia Ras homolog member I (ARHI) results in autophagic cell death of human ovarian cancer cells in vitro (see the related article beginning on page 3917). However, within xenograft tumors in mice, multiple factors within the tumor microenvironment switched ARHI-induced autophagy to a mechanism of tumor cell survival, leading to tumor dormancy. Since ARHI expression is suppressed in the majority of breast and ovarian cancers but is high in premalignant lesions, ARHI-induced autophagy could be manipulated for therapeutic benefit.
[The JCI publishes all research articles immediately in PubMed Central].

See also: Dormant Cancer Cells Rely on Cellular Self-Cannibalization to Survive, News Release, The University of Texas M. D. Anderson Cancer Center, December 31, 2008.

Sunday, October 21, 2007

All Her Life or: Can You Spot the Southern Lady in This Picture?

My mother came in last weekend to Cancer Bitch World HQ. (See photo take by L on porch of CB World HQ.) My mother would have flown in for every chemo treatment, but I wouldn't let her. I asked if she would help me with my clutter, and she agreed. So we spent most of Saturday and Sunday going through the carved wooden buffet I inherited from my grandmother. That's where I keep photos. We filled some albums and threw a lot of pictures away. At first she tore them in half (no going back) but then we just threw them out. It is hard to throw photos out. That's why I needed her there. We pasted some pictures in my baby book, which she'd apparently lost interest in after my first full sentence. She's been diligent about collecting pictures in albums, though--I don't mean to imply that she ever lost interest in recording moments of my life. The book cover is puffy white moire taffeta. I think that's what it's called. It has those whorls and stripes like planks of wood have. The cover says: All Her Life, in pink script, and there's a painted rose with a painting of a little blonde baby sitting inside the flower. It was copyrighted in 1955, the year I was born.

The first thing in there is a congratulatory card for "that basket of joy/The stork just delivered to you!" It's from the local alumnae of my mother's sorority at the University of Texas. This was before sex education in college. Or high school.

My mother didn't fill in the details of our trip home from the hospital, so that page is blank. On the next page is space to put the names of visitors. I filled this in probably in junior high, when I found the book and asked my mother for information. Nine people are listed. Two are alive: my mother's older sister, and an uncle on my father's side. The very first person listed is my mother's friend who died about six years ago of ovarian cancer. My uncle came to visit with my aunt (my father's youngest sister), and she died a few years ago of lung cancer, the kind people get when they don't smoke or haven't smoked for a very very long time. My father's only brother died of lung cancer, the kind that smoker's get.

My baby book expects women to play sports, to go to college, have a philosophy and a career, get married and have a home and children--all reasonable, even progressive assumptions for mid-century. It doesn't necessarily expect the baby to be Jewish. The first clue is a page with an illustration of a baby on it. She's wearing a long white gown edged in pink. There are spaces for my name, its meaning, date, place, officiating clergyman, godmother and -father, notes and those present. What was the occasion? It doesn't say, but I think it's safe to assume it was something that starts with c-h-r-i-s-t. The book finally declares itself on page 22, asking for notes on the baby's first Christmas.

My baby book tells me my first road trip was to Dallas in 1957. My first bus ride was to the San Jacinto Battleground with my kindergarten class. (I remember that. I remember kids chanting, Nixon, Nixon is our man, let's throw Kennedy in the garbage can. And vice versa.) My first train ride was to Dallas in 1958 and my first airplane ride was to New Orleans in 1974. Notes: "Very good traveller, doesn't need dramamine-is very cheerful." That's in my own handwriting.

I discovered my own hands at about two-and-a-half months. I first smiled at about six weeks. I first recognized my mother at about three weeks. I first sat up at about six months. Do I spot a trend? There's more than a whiff of retrospect here. Apparently my mother mother didn't run to the baby book when I reached these milestones.

I had chicken pox in 1959, measles in February 1963, mumps (both sides) June 1964--all this in my mother's hand. In my own: "Pnemonia [sic]-Feb. 1969-was a very good patient." Should I add "Breast cancer, Jan. 2007, very good patient"?

Listed pets:
Gregg, 1963- dachshund
Whitie-goldfish
2 Goldie-goldfish
Blackie-goldfish
Tater, Latke, Sherice, Squeaky-hamsters (I got the original two for Chanukah)
Pretzel, Prince-dogs
April- 1/2 beagle

It does not say that my mother, in one of her worst days in the 1960s, backed her car over Prince. (Didn't your mother kill your dog? my cousin S asked me the last time I saw him.)

As I said, the baby book expected me to have a career. On page 46 there's a picture of a young woman in a blue dress, red hat and white gloves, pondering five gift boxes. They are labeled: Secretarial, Creative, Selling, Manuel [sic], Scientific. Should she go for the guy, Manuel?

Three pages later I'm supposed to be a bride. Then have (in this order) a honeymoon, first home, sports, club activities, first baby. Then have 50 wedding anniversaries. If a parent and daughter were to diligently fill out the pages of this book, they would create a record of a whole life, some kind of whole life. The pages peter out after marriage. Life no longer revolves around the girl-child. It's time for her to start filling out others' baby books, in which she'll have a supporting role.

The reason my mother didn't fill this book out, I think, is that we don't normally think in large blocks of time. We put the photos of the first birthday party into an album, and next, the pictures from the beach two months later, and then of the family trip to Dallas. We don't think to take one photo from each event or year or decade and paste it into a baby or any other kind of book.

But what if we did? What if every New Year's Eve we printed out a couple of representative photos from our desktops and put them in a book, a book with a finite number of bound pages? Is that too frightening to contemplate? This book is called All Her Life. When you get to the end, you're daid. Or sitting in the nursing home, with no one thinking to take your picture or record your first dentures, your first wheelchair, your last meal cooked for yourself, your last wisp of short-term memory. No, there's your golden anniversary, a page for notes, and then it's curtains: "This little book--a happy souvenir/Of all my life--is ended here."