Innovative Researcher Vlog

SU2C Innovative Researcher Vlog: Dr. Lawlor (Pt. 3). Video (3:09 min) posted July 13, 2010. Features Elizabeth R Lawlor, University of Michigan, an SU2C Innovative Research Grants Investigator. [About SU2C (Stand Up to Cancer)]. She provides brief comments about her project: "Modeling Ewing Tumor Initiation in Human Neural Crest Stem Cells". How do normal stem cells become cancer stem cells?

An example of a recent (OA) publication from her laboratory: CD133 expression in chemo-resistant Ewing sarcoma cells by
Xiaohua Jiang and 8 co-authors, including Elizabeth R Lawlor,
BMC Cancer 2010(Mar 26); 10: 116. [FriendFeed entry][PubMed citation][Full text via PMC].

Two recent OA articles

Two articles, with Open Access (OA) to the full text (PDF):

Putative cancer stem cells in malignant pleural mesothelioma show resistance to cisplatin and pemetrexed, Int J Oncol 2010(Aug); 37(2): 437-44. [PubMed citation].

Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance, Oncol Rep 2010(Aug); 24(2): 501-5. [PubMed citation].

Comment about these journals:

Spandidos Publications publishes six journals. Of these six, two are: International Journal of Oncology (2009 Impact Factor: 2.4) and Oncology Reports (2009 Impact Factor: 1.6). This publisher provides a hybrid open access option. The Information for Authors for all six journals includes, at the bottom of the page, this information: "Should authors prefer or require their article to be freely available as soon as it has been published, they may request open access immediately upon publication for a fee of EUR 450."

CSC news links 2010-05-01

For links to recent news items, visit these [Twitter] or [FriendFeed] pages. Examples of two news items that have received attention:

• Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers by Shan Deng and 15 co-authors, including George Coukos and Lin Zhang, PLoS ONE, 2010(Apr 21); 5(4): e10277 [Connbotea bookmark][PubMed Citation][OA full text]. Last sentence of the abstract:

  As a novel cancer stem cell marker, ALDH1 can be used for tumors whose corresponding normal tissues express ALDH1 in relatively restricted or limited levels such as breast, lung, ovarian or colon cancer.

• AACR: Are Cancer Stem Cells Vulnerable to Trastuzumab? By Ed Susman, MedPage Today (Apr 19) [FriendFeed entry][AACR10 abstract]. Excerpt:

  Mathematical modeling suggests that even in women whose breast cancer does not overexpress the HER-2 gene, treatment with trastuzumab (Herceptin) in the adjuvant setting could wipe out cancer stem cells, researchers reported here.

  
  

CSC news links 2010-04-18

For links to recent news items, visit these [Twitter] or [FriendFeed] pages. Examples of a few news items that have received attention:

• Split ends in CML: divergent roles of Hes1 by Catriona Jamieson, Blood 2010(Apr 8); 115(14): 2726-7 [FriendFeed entry][Connotea bookmark][PubMed citation][Full text PDF]. A comment on: Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia by Fumio Nakahara and 13 co-authors, Blood 2010(Apr 8); 115(14): 2872-81. [Epub 2009(Oct 27)][PubMed citation].


• Metabolism and the leukemic stem cell by Omar Abdel-Wahab and Ross L Levine, J Exp Med 2010(Apr 12); 207(4): 677-80 [Epub 2010(Apr 5)][FriendFeed entry][ResearchGATE entry][CiteULike entry][Connotea bookmark][PubMed citation][Full text].


• A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2alpha by Sascha Seidel and 13 co-authors, including Till Acker, Brain 2010(Apr); 133(Pt 4): 983-95 [FriendFeed entry][ResearchGATE entry][Connotea bookmark][PubMed citation].

CSC news roundup 2010-04-11

• Cancer Stem Cells: Back to Darwin? (review) [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/csTyxT


• Cancer stem/progenitor cells are highly enriched in CD133+CD44+ population in hepatocellular carcinoma [FriendFeed entry][PubMed citation] http://bit.ly/bwUz7C


• The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation [FriendFeed entry][News release][PubMed citation] http://bit.ly/cCjVZL


• Hedgehog Signaling and Cancer Stem Cells in Hematopoietic Cell Malignancies (USPTO Application) [FriendFeed entry] http://bit.ly/bSbbTF


• (WO2010037134) Multi-stage stem cell carcinogenesis [FriendFeed entry][WIPO entry] http://bit.ly/cnksOu


• (WO2010037041) Frizzled-binding agents and uses thereof (to target CSC ) [FriendFeed entry] http://bit.ly/aaSJNI


• Epithelial-Mesenchymal Transition (EMT) in Tumor-Initiating Cells and Its Clinical Implications in Breast Cancer (review) [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/cEcBrJ


• Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/cvoGt1


• Emerging strategies for the identification and targeting of cancer stem cells (review) [FriendFeed entry][PubMed citation] http://bit.ly/bGOGfd


• Stem cells in human breast cancer (OA review) [FriendFeed entry][ResearchGATE entry][PubMed citation] http://bit.ly/aF9E8U


• Side-population cells in luminal-type breast cancer have tumour-initiating cell properties, and are regulated by HER2 expression and signalling [FriendFeed entry][PubMed citation] http://bit.ly/92VkLU


• Hypoxia inducible factors in cancer stem cells (minireview) [FriendFeed entry][PubMed citation] http://bit.ly/bGBdxN


• Classic view of cancer challenged by new theory (about the CSC model) [FriendFeed entry] http://bit.ly/decqFe


• New hope in the horizon: cancer stems cells (OA review) [FriendFeed entry][PubGet entry][Full text PDF] http://bit.ly/9HLmV0

CSC news roundup 2010-03-27

• The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/cfLPyK


• Expansion of CD133+ colon cancer cultures retaining stem cell properties to enable cancer stem cell target discovery [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9NLTZ8


• Loss of heterozygosity of the tumor suppressor gene Tg737 in the side population cells of hepatocellular carcinomas is associated with poor prognosis [FriendFeed entry][PubMed citation] http://bit.ly/dCQGYL


• Cancer Stem Cells: The Final Frontier for Glioma Virotherapy [FriendFeed entry][CiteULike entry][PubMed citation] http://bit.ly/c8GeYb


• MUC4 down-regulation reverses chemoresistance of pancreatic cancer stem/progenitor cells and their progenies [FriendFeed entry][ResearchGATE entry][Connotea bookmark][PubMed citation] http://bit.ly/cvcfX7


• Expression of Pluripotent Stem Cell Reprogramming Factors by Prostate Tumor Initiating Cells [FriendFeed entry][PubMed citation] http://bit.ly/9jtqLK


• Molecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cells [FriendFeed entry] [ResearchGATE entry][PubMed citation] http://bit.ly/9xWial


• Cancer stemness and metastasis: Therapeutic consequences and perspectives [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9s0W14


• Gene-expression profiles, tumor microenvironment, and cancer stem cells in breast cancer: Latest advances towards an integrated approach [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/dgqE0n


• Molecular biology of breast cancer stem cells: Potential clinical applications [FriendFeed entry][PubMed citation] http://bit.ly/as3m3j


• In Situ Identification of Putative Cancer Stem Cells by Multiplexing ALDH1, CD44, and Cytokeratin Identifies Breast Cancer Patients with Poor Prognosis [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9rXuWC


• c-Jun Induces Mammary Epithelial Cellular Invasion and Breast Cancer Stem Cell Expansion [FriendFeed entry][PubMed citation] http://bit.ly/aInNB2


• The Utility and Limitations of Neurosphere Assay, CD133 Immunophenotyping and Side Population Assay in Glioma Stem Cell Research [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9O4PtL


• Methods of assaying sensitivity of cancer stem cells to therapeutic modalities (USPTO Application) [FriendFeed entry][FreshPatents entry] http://bit.ly/dcWhtJ


• Cancer Stem Cells [Book and Media Reviews] JAMA 2010(Mar 17);303(11):1098 [FriendFeed entry][Book contents] http://bit.ly/9PY8xP


• Challenges in the development of future treatments for breast cancer stem cells (OA review) [FriendFeed entry] http://bit.ly/9DGutB

CSC news roundup 2010-03-16

• microRNA-34a is tumor suppressive in brain tumors and glioma stem cells [FriendFeed entry][CSC News post][PubMed citation] http://bit.ly/a5onzu


• Enrichment for breast cancer cells with stem/progenitor properties by differential adhesion [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/ceskEY


• miR-29a initiates AML by converting myeloid progenitors into self-renewing leukemia SC? [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9sM8Mw


• Oncolytic viral purging of leukemic hematopoietic stem and progenitor cells with Myxoma virus [FriendFeed entry][PubMed citation] http://bit.ly/c0SRla


• @sciclips MicroRNA as a target for the inhibition of glioblastoma stem cells [FriendFeed entry] http://bit.ly/cvXSwu


• @sciclips The most complete systems biology study of cancer stem cell (CSC) differentiation to date [FriendFeed entry][PubMed citation] http://bit.ly/cBe4D3


• Presentations on Geron’s Telomerase Inhibitor At AACR Special Conference (Business Wire) [FriendFeed entry] http://bit.ly/cFmyWp


• CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9ZmKqT


• Targeting leukemia stem cells (by inducing them to divide) [FriendFeed entry][CiteULike entry][PubMed citation] http://bit.ly/aVquQk


• RT @cancer_news: [Reflection and Reaction] HER2 as a cancer stem-cell target [FriendFeed entry][PubMed citation] http://is.gd/9udQM


• Evidence for self-renewing lung CSCs & their implications [FriendFeed entry][Connotea bookmark][ResearchGATE entry][PubMed citation] http://bit.ly/cje8cc


• Cancer as a reprogramming-like disease: Implications in tumor development and treatment [Connotea bookmark][PubMed citation] http://bit.ly/csHdxT


• RT: @cancer_news Identification of the cell lineage at the origin of basal cell carcinoma [FriendFeed entry][PubMed citation] http://is.gd/9sT10


• Alpha-fetoprotein producing cells act as cancer progenitor cells in human cholangiocarcinoma [FriendFeed entry][CiteULike entry][PubMed citation] http://bit.ly/bp6dnS


• Efficacious Immune Therapy in CML Recognizes Antigens That Are Expressed on CML Progenitor Cells [FriendFeed entry][PubMed citation] http://bit.ly/briNv0


• Notch-Blocking Drugs Kill Brain Cancer Stem Cells http://bit.ly/bQqs4f about [PubMed citation] http://bit.ly/cJZ5e3


• Universal cancer vaccine containing cancer stem cells [FriendFeed entry] http://bit.ly/bDn5R8


• Dock-and-lock (DNL) anti-cancer vaccine for multiple myeloma cancer stem cells [FriendFeed entry] http://bit.ly/csGN8N

MicroRNA-34a is a potential therapeutic agent for glioma SC?

See the open-access article: microRNA-34a is tumor suppressive in brain tumors and glioma stem cells by Fadila Guessous and 7 co-authors, including Roger Abounader, Cell Cycle 2010(Mar 18); 9(6) [Epub ahead of print][FriendFeed entry][PubMed citation]. Last 3 sentences of the Abstract:

The new data show that miR-34a expression inhibits various malignancy endpoints in glioma stem cells. Importantly, they also show for the first time that miR-34a expression induces glioma stem cell differentiation. Altogether, the data suggest that miR-34a is a tumor suppressor and a potential potent therapeutic agent that acts by targeting multiple oncogenic pathways in brain tumors and by inducing the differentiation of cancer stem cells.

CSC news roundup 2010-02-28

• Tumor initiation via loss of cell contact inhibition versus Ras mutation: Do all roads lead to EMT? [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/bIYZjW


• CD133+ cells are more resistant to anticancer drugs than CD133- cells in neuroblastoma cell lines [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/bCJKkI


• Breast cancer chemoresistance: Emerging importance of CSC [FriendFeed entry][ResearchGATE entry][PubMed citation] http://bit.ly/cmgfj4


• Neoplastic stem cells: Current concepts and clinical perspectives [Connotea bookmark][PubMed citation] http://bit.ly/9cRlm2


• Nature Methods: Renaissance of classical pathology? Autofluorescence helps identify CSC in glioma [FriendFeed entry][Connotea bookmark][PubMed citation] http://ow.ly/1ag7d


• New tool illuminates connections between stem cells and cancer [FriendFeed entry] http://bit.ly/9GLmQC


• ALDH Associated With Worse Overall Survival in Patients With Pancreatic Adenocarcinoma [FriendFeed entry][News release][PubMed citation] http://bit.ly/982S5B


• ABCG2: a potential marker of stem cells and novel target in stem cell and cancer therapy [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/clJSiU


• Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9A2kHC


• Radiation Resistance of CSC - The 4R's of Radiobiology Revisited [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/ddLt3N


• Evaluation of the frequency of putative prostate CSC in primary and metastatic prostate cancer [FriendFeed entry][PubMed citation] http://bit.ly/dba5IN


• Immunobiological Characterization of CSC Isolated from Glioblastoma Patients [FriendFeed entry][PubMed citation] http://bit.ly/9t2ReY


• Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer [PubMed citation] http://bit.ly/d17EGn


• Side population and cancer stem cells: therapeutic implications [PubMed citation] http://bit.ly/ceNr2Y


• PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice [FriendFeed entry][CiteULike entry][PubMed citation] http://bit.ly/c9VQTa


• Pancreatic cancer stem cells: new understanding of tumorigenesis, clinical implications [PubMed citation] http://bit.ly/agqb1E


• Targeting Cancer Stem Cells: Therapeutic Strategies and Pipeline Developments (Content, Jan 2010) [FriendFeed entry][BioPortfolio] http://bit.ly/cZzr3R


• Short (<2 min) video about researching pancreatic CSC at UCLA [FriendFeed entry] http://ow.ly/16NCQ


• Lecture: Max Wicha – The CSC hypothesis: biological and clinical implications (57 min) [FriendFeed entry] http://bit.ly/dhKdGD

CSC news roundup 2010-02-13

• ABCG5-positivity in tumor buds is an indicator of poor prognosis in node-negative colorectal cancer patients [FriendFeed entry][Connotea bookmark][PubMed citation][Full text PDF] http://bit.ly/94fqTs


• Good cells gone bad: the cellular origins of cancer [Connotea bookmark][PubMed citation] http://bit.ly/crHb0Y


• Targeted Cancer Stem Cell Therapies Start with Proper Identification of the Target - Letter [Connotea bookmark][PubMed citation] and Response [Connotea bookmark][PubMed citation]


• Transcriptional Profiles of CD133+ and CD133- Glioblastoma-Derived Cancer Stem Cell Lines Suggest Different Cells of Origin [Connotea bookmark][PubMed citation] http://bit.ly/b255Ec


• ALDH1A1(+) cell population enriched in tumor-initiating cells, associated with progression of bladder cancer [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/bDj1yx


• Association of stem cell marker CD133 expression with dissemination of glioblastomas [Sciencia entry][Connotea bookmark][PubMed citation] http://bit.ly/b3azCE


• NO signaling in perivascular niche promotes stem-like characteristics in glioma cells [FriendFeed entry][PubMed citation] http://bit.ly/c8Enie


• TGF-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/bivZQu


• Selective targeting of radiation-resistant tumor-initiating cells [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/chw0Fi


• CSC from colorectal cancer-derived cell lines [FriendFeed entry][News release][PubMed citation] http://bit.ly/bDxxnM


• Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia SC [FriendFeed entry][News release] http://bit.ly/9g8yUJ


• Heterogeneity for Stem Cell-Related Markers According to Tumor Subtype and Histologic Stage in Breast Cancer [Connotea bookmark][PubMed citation] http://bit.ly/aVE3SF


• Hypothesis: co-existing active-quiescent pools of CSC sub-populations? [FriendFeed entry][PubMed citation] http://bit.ly/acMHpi


• Disarming Specialized SC Might Combat Deadly Ovarian Cancer [FriendFeed entry][PubMed citation] http://bit.ly/cTpNTM


• A seminal finding for prostate cancer? [Article summary][Topsy entry][PubMed citation] http://bit.ly/7jCq2n


• Dissecting Cancer Stem Cell Theories [FriendFeed entry] http://bit.ly/9oilZA

CSC news roundup 2010-01-31

• Hypoxia inducible factors in CSC [FriendFeed entry] [Connotea bookmark]


• Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer [FriendFeed entry] http://is.gd/73pVk


• Evidence for self-renewing lung cancer stem cells and their implications [FriendFeed entry] [Connotea bookmark]


• The elaboration of a critical framework for understanding cancer: the CSC hypothesis [FriendFeed entry][Connotea bookmark]


• IMUC’s ICT-107 vaccine product candidate targets CSC [FriendFeed entry] http://bit.ly/5BnV5q


• Putative CSC markers show strong prognostic significance in colorectal cancer [FriendFeed entry][Connotea bookmark] http://bit.ly/7uUuOZ


• Cell of Origin Identified for Common Type of Breast Cancer [FriendFeed entry] http://bit.ly/4B0GOl http://bit.ly/5n9Icz


• Cancer Biomarker Chase Accelerates [FriendFeed entry] http://bit.ly/57iVWN


• CSC suppress immune response against brain tumor [FriendFeed entry] http://bit.ly/6HgW1g


• About a new report: Targeting CSC: Therapeutic Strategies and Pipeline Developments [FriendFeed entry] http://bit.ly/8mfqET


• More evidence that tumours, like healthy organs, grow from SC. The Economist, 14 Jan 2010 [FriendFeed entry] http://bit.ly/4AeekG


• AC133 Epitope, but not the CD133 Protein, Is Lost upon CSC differentiation [FriendFeed entry] http://bit.ly/6r2aGh


• Nanosystems capture and destroy circulating tumor cells (CTC) [FriendFeed entry] http://bit.ly/7ebzXI


• Evidence that CSC escape and down-regulate host antitumor immunity [FriendFeed entry] http://bit.ly/5vWN8n http://bit.ly/5wgRBV


• Stem cells linked to an aggressive cancer of childhood [FriendFeed entry] http://bit.ly/73ldYl http://bit.ly/6YaniV


• Role for the SCF-c-kit signaling axis in self-renewal and proliferation of human lung CSC [FriendFeed entry] http://bit.ly/6PxEyW


• High-throughput screening of tumor-initiating cells in zebrafish [FriendFeed entry] http://bit.ly/6G06No


• The Telomerase Antagonist, Imetelstat, Efficiently Targets Glioblastoma Tumor-Initiating Cells [FriendFeed entry] http://icio.us/t0td2z


• OncoMed, Fluidigm to Analyze Tumor Cell Populations [FriendFeed entry] http://bit.ly/7GnYvm


• Therapy which fails to target CSC can actually promote malignant features in the recurring tumor! [FriendFeed entry] http://bit.ly/6h7jOp


• CXCR1 blockade selectively targets human breast CSC in vitro and in xenografts [FriendFeed entry] http://bit.ly/69ynfK

CSC news roundup 2010-01-16

• Medium and Device for Proliferation of Stem Cells and Treatment of Cancer-Related Stem Cell with Resveratrol, United States Patent Application 20100010099. Via FreePatentsOnline.com. Publication Date: January 14, 2010. Assignees: Taipei Veterans General Hospital. [Patentdocs entry].


• Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content by Salvatore Pece and 9 co-authors, including Pier Paolo Di Fiore, Cell 2010(Jan 8); 140(1): 62-73. [Connotea bookmark][FriendFeed entry].


• Regulating Cancer Stem Cells the miR Way by Marcus E Peter, Cell Stem Cell 2010(Jan 8); 6(1): 4-6. [Commentary on Nat Cell Biol 2009(Dec);11(12):1487-95].


• BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells by Mirle Schemionek and 16 co-authors, including Steffen Koschmieder, Blood 2010(Jan 6) [Epub ahead of print][PubMed Citation][Connotea bookmark].


• Blocking inflammation receptor kills breast cancer stem cells, study finds, News Release, University of Michigan Health System, January 4, 2010. [About: J Clin Invest doi:10.1172/JCI39397][FriendFeed entry][Another FriendFeed entry].


• Geron Announces Publication of Data on Its Telomerase Inhibitor in Glioblastoma, Business Wire, January 4, 2010. [About: Clin Cancer Res 2010(Jan 1);16(1):154-63][FriendFeed entry].


• Primary brain tumors, neural stem cell, and brain tumor cancer cells: Where is the link? By Isabelle Germano, Victoria Swiss and Patrizia Casaccia, Neuropharmacology 2010(Jan 1) [Epub ahead of print][PubMed Citation][Connotea bookmark].


• Cancer Stem Cell Tumor Model Reveals Invasive Morphology and Increased Phenotypical Heterogeneity by Andrea Sottoriva, Joost JC Verhoeff and 6 co-authors, Cancer Res 2010(Jan 1); 70(1): 46-56. [PubMed Citation][FriendFeed entry][ResearchGATE entry].


• The therapeutic promise of the cancer stem cell concept by Natasha Y Frank, Tobias Schatton and Markus H Frank. Review in J Clin Invest 2010(Jan); 120(1): 41-50. [PubMed Citation][ResearchGATE entry].


• Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironment, Breast Cancer Res Treat 2009(Nov 13) [Epub ahead of print][PubMed Citation][MDLinx Oncology Summary][FriendFeed entry].

CSC news roundup 2010-01-03

• Glioma stem cell research for the development of immunotherapy, Neurosurg Clin N Am 2010(Jan); 21(1): 159-66 [PubMed Citation][Connotea bookmark].


• Cancer stem cell and niche, Front Biosci (Schol Ed) 2010(Jan 1); 2: 184-93 [PubMed Citation][FriendFeed entry][Connotea bookmark].


• Cancer stem cell niche as a therapeutic target by Alexey Bersenev, Hematopoiesis, December 27, 2009 [FriendFeed entry].


• Leukemia Stem Cells, Semin Cancer Biol 2009(Dec 22) [Epub ahead of print][PubMed Citation][Connotea bookmark].


• Aldehyde Dehydrogenase 1–Positive Cancer Stem Cells Mediate Metastasis and Poor Clinical Outcome in Inflammatory Breast Cancer, Clin Cancer Res 2009(Dec 22) [Epub ahead of print][PubMed Citation][FriendFeed entry][Connotea bookmark].


• Multiple lineages of human breast cancer stem/progenitor cells identified by profiling with stem cell markers, PLoS ONE 2009(Dec 21); 4(12): e8377 [PubMed Citation][Full text via PMC][ResearchGATE entry][Connotea bookmark].


• Are cancer stem cells concentrated in more alkaline hypoxic regions of tumors? Med Hypotheses 2009(Dec 16)[Epub ahead of print][PubMed Citation].


• Targeted therapy in haematological malignancies, J Pathol 2009(Dec 10) [Epub ahead of print][PubMed Citation][ResearchGATE entry][Connotea bookmark].


• Video of Robert Weinberg interviewed about Breast Cancer Stem Cells & the EMT, SABCS 2009 Interview, American Association for Cancer Research, December 10, 2009 [FriendFeed entry].


• Professor Dick Honored For Making Sense of Cancer Stem Cells by Mikkael A Sekeres, ASH News Daily, December 8, 2009 [FriendFeed entry].


• Spices halt growth of breast stem cells, study finds, PhysOrg.com, December 7, 2009 [FriendFeed entry].

CSC news roundup 2009-12-24

• An adult tissue-specific stem cell molecular phenotype is activated in epithelial cancer stem cells and correlated to patient outcome by Thomas Hussenet and 4 co-authors, including Stanislas du Manoir, Cell Cycle 2010(Jan 23); 9(2) [Epub ahead of print][PubMed Citation][Connotea bookmark].


• Differential Destruction of Stem Cells: Implications for Targeted Cancer Stem Cell Therapy by Mary E Sehl and 3 co-authors, including Kenneth L Lange, Cancer Res 2009(Dec 15); 69(24): 9481-9 [PubMed Citation][Connotea bookmark][ResearchGATE entry].


• EZH2 Is Essential for Glioblastoma Cancer Stem Cell Maintenance by Mario-Luca Suvà and 12 co-authors, including Ivan Stamenkovic, Cancer Res 2009(Dec 15); 69(24): 9211-8 [PubMed Citation][Connotea bookmark].


• Hypoxia-Regulated Delta-like 1 Homologue Enhances Cancer Cell Stemness and Tumorigenicity by Yuri Kim and 3 co-authors, including Zhong Yun, Cancer Res 2009(Dec 15); 69(24): 9271-80 [PubMed Citation][Connotea bookmark].


• Cancer Stem Cells and Aneuploid Populations within Developing Tumors Are the Major Determinants of Tumor Dormancy by Anjali P Kusumbe and Sharmila A Bapat, Cancer Res 2009(Dec 15); 69(24): 9245-53 [PubMed Citation][ResearchGATE entry].


• Stem-like cancer cells are inducible by increasing genomic instability in cancer cells by Yi Liang and 9 co-authors, including Yi-Xin Zeng, J Biol Chem 2009(Dec 9) [Epub ahead of print][PubMed Citation][Early version of full text].


• Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells by Michiko Murohashi and 9 co-authors, including Noriko Gotoh, Br J Cancer 2009(Dec 8) [Epub ahead of print][PubMed Citation][ResearchGATE entry].


• Brain Tumor Cells Made More Responsive to Radiation, ScienceDaily, December 3, 2009 [Stem Cells 2009(Nov 17)]][PubMed Citation].


• SOM scientists explore spice as complementary treatment option for colorectal cancer, Prognosis E-news, Wayne State University School of Medicine, November 24, 2009 [Transl Oncol 2009(Dec);2(4):321-8][PubMed Citation].


• Is ALDH1 a good method for definition of breast cancer stem cells? by Veronique Neumeister and David Rimm, Breast Cancer Res Treat 2009(Nov 28) [Epub ahead of print][PubMed Citation][Connotea bookmark].


• Single-Cell STAT5 Signal Transduction Profiling in Normal and Leukemic Stem and Progenitor Cell Populations Reveals Highly Distinct Cytokine Responses by Lina Han and 5 co-authors, including Jan Jacob Schuringa, PLoS ONE 2009(Nov 24); 4(11): e7989 [PubMed Citation][Full text in PMC][Connotea bookmark].


• Recurrent hepatocellular carcinoma cells with stem cell-like properties: possible targets for immunotherapy by Xiaolan Xu‌ and 8 co-authors, including Zhiqian Zhang‌, Cytotherapy 2009(Nov 24) [Epub ahead of print][PubMed Citation][Connotea bookmark].

CSC news roundup 2009-11-26

• Distinct population of highly malignant cells in a head and neck squamous cell carcinoma cell line established by xenograft model, 7thSpace Interactive, November 16, 2009 [J Biomed Sci 2009(Nov 16);16(1):100 (OA)][PubMed Citation][FriendFeed entry].


• Tumor-initiating Cells Detected in Pten Null Prostate Cancer Model, PhysOrg.com, November 12, 2009 [Cancer Res 2009(Nov 15); 69(22):8555-62][PubMed Citation][FriendFeed entry].


• Mouse Models for Cancer Stem Cell Research by Le Cheng and 4 co-authors, including Alexander Y Nikitin, Toxicol Pathol 2009(Nov 17) [Epub ahead of print][PubMed Citation].


• Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironment by Erika Resetkova and 6 co-authors, including Sunil Badve, Breast Cancer Res Treat 2009(Nov 13) [Epub ahead of print][PubMed Citation][Connotea bookmark].


• Recognition and Killing of Brain Tumor Stem-Like Initiating Cells by CD8+ Cytolytic T Cells by Christine E Brown and 10 co-authors, including Michael C Jensen, Cancer Res 2009(Nov 10) [Epub ahead of print][PubMed Citation][Connotea bookmark].


• Notch Pathway Blockade Depletes CD133-Positive Glioblastoma Cells and Inhibits Growth of Tumor Neurospheres and Xenografts by Xing Fan and 14 co-authors, including Charles G Eberhart, Stem Cells 2009(Nov 10) [Epub ahead of print][PubMed Citation][Connotea bookmark].


• Targeting breast stem cells with the cancer preventive compounds curcumin and piperine by Madhuri Kakarala and 8 co-authors, including Max S Wicha, Breast Cancer Res Treat 2009(Nov 7) [Epub ahead of print][PubMed Citation].


• Identification of single chain antibodies to breast cancer stem cells using phage display by Deniz Gur and 5 co-authors, including Max S Wicha and David N Krag, Biotechnology Prog 2009(Nov 6) [Epub ahead of print][PubMed Citation].


• Methodologies in assaying prostate cancer stem cells by Hangwen Li and 7 co-authors, including Dean G Tang, Methods Mol Biol 2009; 568: 85-138 [PubMed Citation].


• Pituitary adenoma stem cells by Patrizia Tunici and John S Yu, Methods Mol Biol 2009; 568: 195-201 [PubMed Citation].


• Targeting breast cancer stem cells by Max S Wicha, The Breast 2009(Oct); 18(Suppl 3): S56-8.

CSC news roundup 2009-11-10

• The cancer stem cell microenvironment and anti-cancer therapy by Veerander P S Ghotra, Jordi C Puigvert and Erik H J Danen. Review in Int J Radiat Biol 2009(Nov); 85(11): 955-62 [PubMed Citation].


• Cancer Stem Cells : A Reality, A Myth, A Fuzzy Concept or A Misnomer? An Analysis by Carine Maenhaut, Jacques E Dumont, Pierre Roger and Wilma C G van Staveren. Review in Carcinogenesis 2009(Oct 25) [Epub ahead of print][PubMed Citation].


• Colorectal cancer stem cells by Paul Salama and Cameron Platell, Review in ANZ J Surg 2009(Oct); 79(10): 697-702 [PubMed Citation][FriendFeed entry].


• Identification and targeting of cancer stem cells by Tobias Schatton, Natasha Y Frank and Markus H Frank. Review in Bioessays 2009(Oct); 31(10): 1038-49 [PubMed Citation].


• Cancer stem cells: Symmetry is key by Mhairi Skinner, Nature Reviews Cancer 2009; 9: 768-9. A commentary about [Cell 2009 Sep 18;138(6):1083-95][FriendFeed entry].


• On cancer stem cells (for the lay public) [All Things Stem Cell 2009(Oct 31)] by Teisha Rowland [FriendFeed entry].


• Immunoselection of breast and ovarian cancer cells with trastuzumab and natural killer cells. [Cancer Res 2009(Oct 15);69(20):8058-66][PubMed Citation][FriendFeed entry].


• CD133 Expression Defines a Tumor Initiating Cell Population in Primary Human Ovarian Cancer by Michael D Curley and 10 co-authors, including Bo R Rueda and Rosemary Foster. Stem Cells 2009(Oct 8) [Epub ahead of print][PubMed Citation].

CSC news roundup: 2009-11-02

• Compositions and Methods for Determining Cancer Stem Cell Self-Renewal Potential, University of California, San Diego Technology Transfer Office, November 2, 2009. [SD2009-192][Tech ID: 19976].


• ImmunoCellular's Promising Brain Cancer Vaccine, Mike Havrilla, Seeking Alpha, October 28, 2009. [Reuters News Release].


• MicroRNA Regulation of Cancer Stem Cells and Therapeutic Implications, Jeffrey T DeSano and Liang Xu, AAPS J 2009(Oct 20). [PubMed Citation].


• Sphere and/or xenograft formation may be useful to survey colitic patients at risk of developing cancer? [Cancer Res 2009 (Oct 15);69(20):8208-15][PubMed Citation][News Release].


• Recent studies regarding stem cell origin of various solid tumors are discussed briefly in this review. [Onkologie 2009 (Oct);32(10):605-9][PubMed Citation].


• Squelching glioblastoma stem cells by targeting REST for proteasomal degradation by Peisu Zhang and 4 co-authors, including Jeremy N Rich and Mark P Mattson, Trends Neurosci 2009(Nov);32(11):559-65 [Epub 2009(Sep 11)][PubMed Citation].


• Methylation dosage effect controls stem cell function in leukemia. [Nat Genet 2009 (Nov);41(11):1207-15][PubMed Citation][News Release].

CSC targeted to prevent relapse

Cancer stem cells targeted to prevent relapse by Vivek Sinanan, The Johns Hopkins News-Letter, October 26, 2009. In part, the news item appears to be based on this editorial: Controversies in cancer stem cells by Richard J Jones, J Mol Med 2009(Oct 23) [Epub ahead of print][PubMed Citation][Full text]. In turn, the editorial cites these articles, which will be published in J Mol Med 2009; 87(11):

• Cancer stem cells: controversies in multiple myeloma, Sarah K Brennan, William Matsui, J Mol Med 2009(Sep 17) [Epub ahead of print][PubMed Citation].


• Brain cancer stem cells, Sara GM Piccirillo and 4 co-authors, including Khalid Shah, J Mol Med 2009(Sep 29) [Epub ahead of print][PubMed Citation].


• Colon cancer stem cells, Lucia Ricci-Vitiani and 4 co-authors, including Ruggero De Maria, J Mol Med 2009(Sep 2) [Epub ahead of print][PubMed Citation].


• Cancer stem cells-clinical relevance, Richard J Jones, J Mol Med 2009(Oct 10) [Epub ahead of print][PubMed Citation].