An intensive care and support is always most vital for mesothelioma patients. They sometime work more than medicine and doctor. Mesothelioma is a rare cancer. The main cause for this cancer is due to inhalation of dangerous fiber called asbestos which was used in many industries in twentieth century. These asbestos, when inhaled for long time, trigger the formation of malignant cells in the internal organs. Although scientists have no clue how exactly the asbestos works and creates this deadly cells. But they do know that as soon as asbestos reaches inside, there is big chance that the person, who inhaled the asbestos, will suffer from mesothelioma anytime soon.
Mesothelioma patients may have different symptoms such as consistent cough, chest pain, breathing problem, anemia, problem in bowl, sudden loss in weight and others. These symptoms are visible in the patients, but this may be related to other diseases. To confirm, there are various ways to find out. Doctors suggest doing CT scan, X-ray and MRI. Furthermore, a biopsy is suggested to make more confirmation. However, the symptoms are usually seen after many years, and at that time, it might be too late. A regular checkup in hospital, click from experienced doctors is always recommended.
The treatment of mesothelioma cancers are started as soon as they are diagnosed. Mesothelioma patients are given Chemotherapy, Radiotherapy and do Surgery when possible. Surgery is done when the cancer is in its initial stage. When the cancer crosses second stage and reaches third, the mesothelioma patients are given chemotherapy which is very good and help in increase lifespan. However there are many other treatments which are practiced by doctors and other medical practitioners with mesothelioma patients. Those treatments have some benefits for some patients. Most importantly, the early detection is the way to eliminate the cancer from the root. With the positive attitude and confidence, mesothelioma patients can fight it and win the battle.
Showing posts with label radiotherapy. Show all posts
Showing posts with label radiotherapy. Show all posts
Thursday, March 10, 2011
Monday, March 7, 2011
Top 20 Treatment Options For Mesothelioma
1. There are three options available, for Mesothelioma. One is surgery (taking out the cancer).
2. Chemotherapy (using drugs to combat the cancer).
3. The last is radiation therapy, by which high-dose X-rays or other high-energy rays are used to kill the cancer cells.
4. Surgery is one of the options available, but it has largely proved disappointing. For better success, it can be combined with chemotherapy and radiation. The most common surgery is a pleurectomy / decortication – the removal of the lining of the chest.
5. Another kind of surgery available is the extrapleural pneumonectomy (EPP) – the removal of the lung, lining of the chest’s inside, the pericardium, and the hemi-diaphragm.
6. Radiation is used post-operation as a consolidative treatment. Radiation is given to the hemi-thorax region, sometimes with chemotherapy.
7. Chemotherapy is perhaps the most effective treatment.
8. Immunotherapy is also used – the body is injected with intrapleural inoculation of Bacillus Calmette-Guerin (BCG), though this has not proven very effective.
9. Mesothelioma cells can be treated with in-vitro lysis by LAK cells, following activation by interleukin-2 (IL-2), but this may have side effects.
10. Heated intraoperative intraperitoneal chemotherapy is also used. As much of the tumor as possible is removed, then a chemotherapy agent is directly administered, temperature of between 40 and 48 degrees Celsius, to the abdomen.
11. Chest tube drainage is used for the case of pleural effusion – building up of fluid.
12. Chemical pleurodesis is used in the case of pleural effusion – by this, a sclerosing agent is used to abrade the pleural surface, and this produces an adhesion between the parietal and visceral pleurae. Talc is the most effective agent for pleurodesis.
13. The pleural space is closed by the chest tube drainage treatment.
14. Thoracoscopy and Pleurodesis are used, with VATS, using a powdered form of talc, versus talc slurry. This will only prove effective if the lung is not encased by any tumor, this restricts the expansion.
15. Pleurectomy is performed if extensive surgery is ruled out. In such cases, all the tumor visible will not be removed. This is extremely effective for controlling pleural effusion if disease restricts the expansion of the lung.
16. In Pleuroperitoneal Shunt, a catheter is placed, running from under the skin from the pleural to the peritoneal cavity.
17. Extrapleural Pneumonectomy is a more radical surgical approach, which is currently being combined with chemotherapy and/or radiation, or even new approaches like gene therapy and photodynamic therapy.
18. For peritoneal Mesothelioma, cytoreductive surgery is performed, which aims to remove all or nearly all the gross or visible tumor in the peritoneal cavity. The remaining cancer cells are treated with Intra-Peritoneal Hyperthermic (heated) Chemotherapy (IPHC), which is then sent to the abdominal cavity.
19. The neoadjuvant approach is used in chemotherapy – where Alimta is used with Cisplatin, for patients who have malignant pleural Mesothelioma. This has been specially approved by the Food and Drug Administration.
20. Chemotherapy is administered intravenously, through a vein. A thin needle is inserted into a vein in the lower arm, or in the hand – and drugs rapidly enter into the blood stream. They may also be delivered through catheters and/or ports.
2. Chemotherapy (using drugs to combat the cancer).
3. The last is radiation therapy, by which high-dose X-rays or other high-energy rays are used to kill the cancer cells.
4. Surgery is one of the options available, but it has largely proved disappointing. For better success, it can be combined with chemotherapy and radiation. The most common surgery is a pleurectomy / decortication – the removal of the lining of the chest.
5. Another kind of surgery available is the extrapleural pneumonectomy (EPP) – the removal of the lung, lining of the chest’s inside, the pericardium, and the hemi-diaphragm.
6. Radiation is used post-operation as a consolidative treatment. Radiation is given to the hemi-thorax region, sometimes with chemotherapy.
7. Chemotherapy is perhaps the most effective treatment.
8. Immunotherapy is also used – the body is injected with intrapleural inoculation of Bacillus Calmette-Guerin (BCG), though this has not proven very effective.
9. Mesothelioma cells can be treated with in-vitro lysis by LAK cells, following activation by interleukin-2 (IL-2), but this may have side effects.
10. Heated intraoperative intraperitoneal chemotherapy is also used. As much of the tumor as possible is removed, then a chemotherapy agent is directly administered, temperature of between 40 and 48 degrees Celsius, to the abdomen.
11. Chest tube drainage is used for the case of pleural effusion – building up of fluid.
12. Chemical pleurodesis is used in the case of pleural effusion – by this, a sclerosing agent is used to abrade the pleural surface, and this produces an adhesion between the parietal and visceral pleurae. Talc is the most effective agent for pleurodesis.
13. The pleural space is closed by the chest tube drainage treatment.
14. Thoracoscopy and Pleurodesis are used, with VATS, using a powdered form of talc, versus talc slurry. This will only prove effective if the lung is not encased by any tumor, this restricts the expansion.
15. Pleurectomy is performed if extensive surgery is ruled out. In such cases, all the tumor visible will not be removed. This is extremely effective for controlling pleural effusion if disease restricts the expansion of the lung.
16. In Pleuroperitoneal Shunt, a catheter is placed, running from under the skin from the pleural to the peritoneal cavity.
17. Extrapleural Pneumonectomy is a more radical surgical approach, which is currently being combined with chemotherapy and/or radiation, or even new approaches like gene therapy and photodynamic therapy.
18. For peritoneal Mesothelioma, cytoreductive surgery is performed, which aims to remove all or nearly all the gross or visible tumor in the peritoneal cavity. The remaining cancer cells are treated with Intra-Peritoneal Hyperthermic (heated) Chemotherapy (IPHC), which is then sent to the abdominal cavity.
19. The neoadjuvant approach is used in chemotherapy – where Alimta is used with Cisplatin, for patients who have malignant pleural Mesothelioma. This has been specially approved by the Food and Drug Administration.
20. Chemotherapy is administered intravenously, through a vein. A thin needle is inserted into a vein in the lower arm, or in the hand – and drugs rapidly enter into the blood stream. They may also be delivered through catheters and/or ports.
Sunday, March 6, 2011
Radiotherapy for Mesothelioma Cancer
Management options both for patients who bonk had surgery and those for which surgery is not an option nearly ever includes chemotherapy and radiotherapy. This communicating way uses irradiation to punish cancerous cells; it is perhaps the oldest non-surgical direction for malignance in Western medicine. Radioherapy can be effectual in killing human cells but it is not a real finespun discipline, so the emission beams lean to terminate rubicund cells contiguous to the malignant cells on which it is targeted.
Because of the limitations for emission - precision and the depth to which it can be operative - a medico performing a resection machine on a patient may accomplish a syndrome management for mesothelioma piece the uncomplaining is soothe in surgery and the position of the disease is exposed. Withal emission treatments are included in virtually any management show for mesothelioma, whether surgery is interested or not. Radioactivity is old to battle cancerous cells and to ply both of the symptoms much as pleural gush associated with mesothelioma.
Because of the limitations for emission - precision and the depth to which it can be operative - a medico performing a resection machine on a patient may accomplish a syndrome management for mesothelioma piece the uncomplaining is soothe in surgery and the position of the disease is exposed. Withal emission treatments are included in virtually any management show for mesothelioma, whether surgery is interested or not. Radioactivity is old to battle cancerous cells and to ply both of the symptoms much as pleural gush associated with mesothelioma.
Saturday, June 20, 2009
CSC and radiotherapy
Cancer stem cells and radiotherapy by Michael Baumann and 4 co-authors, Int J Radiat Biol 2009(May); 85(5): 391-402 [PubMed Citation][Full text is publicly accessible (via Gratis OA)][Found via ResearchGATE, see: publication link].
In this review, the authors question the interpretation of data in a much-cited article by Shideng Bao and 8 co-authors, including Jeremy N Rich, entitled: Glioma stem cells promote radioresistance by preferential activation of the DNA damage response, Nature 2006(Dec 7); 444(7120): 756-60 [Epub 2006 Oct 18][PubMed Citation][Full text PDF is publicly accessible (via Gratis OA)][Another publicly accessible version].
Excerpt from the review by Baumann et al. 2009:
Another excerpt from Baumann et al. 2009:
In this review, the authors question the interpretation of data in a much-cited article by Shideng Bao and 8 co-authors, including Jeremy N Rich, entitled: Glioma stem cells promote radioresistance by preferential activation of the DNA damage response, Nature 2006(Dec 7); 444(7120): 756-60 [Epub 2006 Oct 18][PubMed Citation][Full text PDF is publicly accessible (via Gratis OA)][Another publicly accessible version].
Excerpt from the review by Baumann et al. 2009:
However, interpretation of these data [of Boa et al] is limited by several factors including the fact that enrichment of CD133+ cells after irradiation may possibly reflect differences in proliferative capability rather than differences in radiosensitivity, and that the irradiation dose of 2 Gy might not be sufficient to generate detectable differences in the transplantation assay used (Baumann et al. 2008).[PubMed Citation for the reference to Baumann et al. 2008].
Another excerpt from Baumann et al. 2009:
In summary, a higher radioresistance of cancer stem cells compared to non-stem cells has not been proven. More experiments, comparing the results of surface-marker based quantitative transplantation assays with and without irradiation after different doses in different tumours, are necessary before firm conclusions on the radioresistance of cancer stem cells can be drawn.Comment: The intrinsic radiosensitivity of cancer stem cells compared to non-stem cells is, from the perspective of radiation oncology, an important issue that has been investigated for many years. Some of this history is reviewed by Baumann et al. 2009. The issue needs to be resolved.
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